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KMID : 0617320010100010055
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.55 ~ p.60
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Studies on the Screening of Bioactive Compound Acting on Intracellular Enzymes from Natural Products and Its Mode of Action
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Abstract
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Puerariae Radix is one of the medicinal plants used in oriental medicine for hangover. It has been claimed for several pharmacological effects including anti-alchol abuse, antidipsotropic activity and anti-alcohol intoxication. In connection with Puerariae Radix effects, an activity-guided purification of active substance on alcohol dehydrogenase(ADH) was carried-out. The most active compound was isolated as puerarin (C_21H_20O_9), molecular weight 416. Puerarin inhibited ADH noncompetitively against ethanol or NAD^+
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